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1

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Mark E. Schnute, Patrick M. O’Brien, Joe Nahra, Mark Morris, W. Howard Roark, Cathleen E. Hanau, Peter G. Ruminski, Jeffrey A. Scholten, Theresa R. Fletcher, Bruce C. Hamper, Jeffery N. Carroll, Willi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

2

Regioselective synthesis of 1-methyl-3-hydroxy-5-perfluoroalkylpyrazoles by the addition of methylhydrazine to perfluoroalkylacetylenic esters

Bruce C. Hamper

Journal:

Journal of Fluorine Chemistry

Year:

1990

Language:

english

File:

PDF, 474 KB

english, 1990

3

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry

Regalado, Erik L., Kozlowski, Marisa C., Curto, John M., Ritter, Tobias, Campbell, Michael G., Mazzotti, Anthony R., Hamper, Bruce C., Spilling, Christopher D., Mannino, Michael P., Wan, Li, Yu, Jin-Q

Journal:

Organic & Biomolecular Chemistry

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

4

Synthesis of highly substituted 5-(trifluoromethyl)ketoimidazoles using a mixed-solid/solution phase motif

Bruce C. Hamper, Kevin D. Jerome, Gopi Yalamanchili, Daniel M. Walker, Robert C. Chott, Deborah A. Mischke

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 220 KB

english, 2000

5

ChemInform Abstract: Preparation of Small Molecule Libraries for Agrochemical Discovery. Development of Parallel Solution and Solid Phase Synthesis Methods

Bruce C. Hamper, Thomas J. Owen, Kevin D. Jerome, Angela S. Scates, Stephen A. Kolodziej, Robert C. Chott, Allen S. Kesselring

Journal:

Year:

2001

File:

PDF, 25 KB

2001

6

Reaction of Benzohydroximinoyl Chlorides and β-(Trifluoromethyl)acetylenic Esters: Synthesis of Regioisomeric (Trifluoromethyl)isoxazolecarboxylate Esters and Oxime Addition Products.

Bruce C. Hamper, Kindrick L. Leschinsky

Journal:

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

7

Reaction of benzohydroximinoyl chlorides and β-(trifluoromethyl)-acetylenic esters: Synthesis of regioisomeric (trifluoromethyl)-isoxazolecarboxylate esters and oxime addition products

Bruce C. Hamper, Kindrick L. Leschinsky

Journal:

Journal of Heterocyclic Chemistry

Year:

2003

Language:

english

File:

PDF, 82 KB

english, 2003

8

Analytical and preparative separation of the enantiomers of pyrazole phenyl ether herbicides on three chiral stationary phases

Bruce C. Hamper, Daniel R. Dukesherer, Kurt Moedritzer

Journal:

Journal of Chromatography A

Year:

1994

Language:

english

File:

PDF, 547 KB

english, 1994

9

Solid-phase synthesis of proline analogs via a three component 1,3-dipolar cycloaddition

Bruce C. Hamper, Daniel R. Dukesherer, Michael S. South

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 225 KB

english, 1996

10

Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones

Stephen A. Kolodziej, Bruce C. Hamper

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 234 KB

english, 1996

11

A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers

William H. Pirkle, Myung Ho Hyun, Athanasios Tsipouras, Bruce C. Hamper, Bernadine Banks

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1984

Language:

english

File:

PDF, 497 KB

english, 1984

12

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Jane L. Wang, David Limburg, Matthew J. Graneto, John Springer, Joseph Rogier Bruce Hamper, Subo Liao, Jennifer L. Pawlitz, Ravi G. Kurumbail, Timothy Maziasz, John J. Talley, James R. Kiefer, Jeffery

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 811 KB

english, 2010

13

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates

Jane L. Wang, Karl Aston, David Limburg, Cindy Ludwig, Ann E. Hallinan, Francis Koszyk, Bruce Hamper, David Brown, Matthew Graneto, John Talley, Timothy Maziasz, Jaime Masferrer, Jeffery Carter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 742 KB

english, 2010

14

Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors

Li Xing, Bruce C. Hamper, Theresa R. Fletcher, Jay M. Wendling, Jeffery Carter, James K. Gierse, Subo Liao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

15

Chromatographic separation of the enantiomers of 1,3-dithiolane-1-oxides

William H. Pirkle, Bruce C. Hamper

Journal:

Journal of Chromatography A

Year:

1988

Language:

english

File:

PDF, 894 KB

english, 1988

16

Solid phase synthesis of dihydropyrimidinones and pyrimidinone carboxylic acids from malonic acid resin

Bruce C. Hamper, Kevin Z. Gan, Thomas J. Owen

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 247 KB

english, 1999

17

Knoevenagel condensation of unsymmetrical malonamic esters and malonates on a solid support

Bruce C. Hamper, Stephen A. Kolodziej, Angela M. Scates

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 206 KB

english, 1998

18

Setting-based Practice Variation in the Management of Simple Febrile Seizure

Louis C. Hampers, Jennifer L. Trainor, Robert Listernick, Jennifer J. Eddy, David A. Thompson, Edward P. Sloan, Oliver P. Chrisler, Leonora M. Gatewood, Bruce McNulty, Steven E. Krug

Journal:

Academic Emergency Medicine

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

19

Studies on the metabolism of aldosterone in chronic renal failure and anephric man

Williams, Gordon H, Bailey, George L, Hampers, Constantine L, Lauler, David P, Merrill, John P, Underwood, Richard H, Blair-West, John R, Coghlan, John P, Denton, Derek A, Scoggins, Bruce A

Journal:

Kidney International

Year:

1973

Language:

english

File:

PDF, 726 KB

english, 1973

20

Cyclocondensation of alkylhydrazines and .beta.-substituted acetylenic esters: synthesis of 3-hydroxypyrazoles

Hamper, Bruce C., Kurtzweil, Mitchell L., Beck, James P.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 929 KB

english, 1992

21

The carboxyterminal processing protease of D1 protein: Herbicidal activity of novel inhibitors of the recombinant and native spinach enzymes

Stephen M.G. Duff, Yun-Chia Sophia Chen, Brad J. Fabbri, Gopichand Yalamanchili, Bruce C. Hamper, Dan M. Walker, Frederick A. Brookfield, Edward A. Boyd, Mark R. Ashton, Christopher J. Yarnold, Claire

Journal:

Pesticide Biochemistry and Physiology

Year:

2007

Language:

english

File:

PDF, 598 KB

english, 2007

22

Effects of Isoxazole Herbicides on Protoporphyrinogen Oxidase and Porphyrin Physiology

Dayan, Franck E., Duke, Stephen O., Reddy, Krishna N., Hamper, Bruce C., Leschinsky, Kindrick L.

Journal:

Journal of Agricultural and Food Chemistry

Year:

1997

Language:

english

File:

PDF, 215 KB

english, 1997

23

Solid Phase Synthesis of β-Peptoids: N-Substituted β-Aminopropionic Acid Oligomers

Hamper, Bruce C., Kolodziej, Stephen A., Scates, Angela M., Smith, Ronald G., Cortez, Enriqueta

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 158 KB

english, 1998

24

Synthesis of 1H-pyrazolo[3,4-d]pyrimidines via solid-phase Aza-Wittig/electrocyclic ring closure reaction

Liao, Subo, Xing, Li, Hamper, Bruce

Journal:

Tetrahedron Letters

Year:

2013

Language:

english

File:

PDF, 462 KB

english, 2013

25

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

Carron, Chris P., Trujillo, John I., Olson, Kirk L., Huang, Wei, Hamper, Bruce C., Dice, Tom, Neal, Bradley E., Pelc, Matthew J., Day, Jacqueline E., Rohrer, Douglas C., Kiefer, James R., Moon, Joseph

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.48 MB

english, 2010

26

Corroboration of techniques for assigning absolute configuration: lacinilene C methyl ether as an exemplary study

Stipanovic, Robert D., McCormick, John P., Schlemper, Elmer O., Hamper, Bruce C., Shinmyozu, Teruo, Pirkle, William H.

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 730 KB

english, 1986

27

High-Throughput 1 H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library

Hamper, Bruce C., Snyderman, David M., Owen, Thomas J., Scates, Angela M., Owsley, Dennis C., Kesselring, Allen S., Chott, Robert C.

Journal:

Journal of Combinatorial Chemistry

Year:

1999

Language:

english

File:

PDF, 214 KB

english, 1999

28

Direct synthesis of .beta.-ketomethylenetriphenylphosphoranes from readily available phosphonium salts

Hamper, Bruce C.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 723 KB

english, 1988

29

Parallel Solid-Phase Synthesis and High-Throughput 1 H NMR Evaluation of a 96-Member 1,2,4-Trisubstituted-pyrimidin-6-one-5-carboxylic Acid Library

Hamper, Bruce C., Kesselring, Allen S., Chott, Robert C., Yang, Shengtian

Journal:

Journal of Combinatorial Chemistry

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

30

A widely useful chiral stationary phase for the high-performance liquid chromatography separation of enantiomers

Pirkle, William H., Finn, John M., Schreiner, James L., Hamper, Bruce C.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 343 KB

english, 1981

31

Direct Uncatalyzed Amination of 2-Chloropyridine Using a Flow Reactor

Hamper, Bruce, Tesfu, Eden

Journal:

Year:

2007

Language:

english

File:

PDF, 114 KB

english, 2007

32

Discovery of N -(4-Fluoro-3-methoxybenzyl)-6-(2-(((2 S ,5 R )-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2 H -tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

Ruminski, Peter G., Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E., Schmidt, Michelle, Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Shieh, Huey S., Caspers, N

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 995 KB

english, 2015

33

A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates

Roy, Sudeshna, Sutivisedsak, Nongnuch, Hamper, Bruce, Lyss, Alexander, Spilling, Christopher

Journal:

Year:

2015

Language:

english

File:

PDF, 175 KB

english, 2015

34

Enantioseparation of α-Hydroxyallylphosphonates and Phosphonoallylic Carbonate Derivatives on Chiral Stationary Phases Using Sequential UV, Polarimetric, and Refractive Index Detection

Hamper, Bruce C., Mannino, Michael P., Mueller, Melissa E., Harrison, Liam T., Spilling, Christopher D.

Journal:

Year:

2016

Language:

english

File:

PDF, 204 KB

english, 2016

35

A Practical Gram-Scale Synthesis of Acrylohydroxamic Acid

Hamper, Bruce, Sullivan, Brendan, Rath, Nigam, Spilling, Christopher

Journal:

Year:

2017

Language:

english

File:

PDF, 223 KB

english, 2017

36

Rapid Determination of Humulones and Isohumulones in Beers Using MISER LC-MS Analysis

Hamper, Bruce C., Zawatzky, Kerstin, Zhang, Vivian, Welch, Christopher J.

Journal:

Journal of the American Society of Brewing Chemists

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

37

Introducing Nonscience Majors to Science Literacy via a Laboratory and Lecture Beer Brewing Course

Hamper, Bruce C., Meisel, Joseph W.

Journal:

Journal of Chemical Education

Year:

2020

Language:

english

File:

PDF, 3.28 MB

english, 2020

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